DNA replication stress: oncogenes in the spotlight
نویسندگان
چکیده
منابع مشابه
IN THE SPOTLIGHT Climbing RAS, the Everest of Oncogenes
Authors’ Affi liations: 1 University of Turin, Department of Oncology, Candiolo (TO); 2 IRCC, Institute for Cancer Research and Treatment at Candiolo, Candiolo (TO); 3 FIRC Institute of Molecular Oncology (IFOM), Milan, Italy. Corresponding Author: Alberto Bardelli, University of Turin, Department of Oncology, IRCC, Institute for Cancer Research and Treatment at Candiolo, SP 142, Candiolo, Tori...
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Both Myc and Ras oncogenes impact cellular metabolism, deregulate redox homeostasis and trigger DNA replication stress (RS) that compromises genomic integrity. However, how are such oncogene-induced effects evoked and temporally related, to what extent are these kinetic parameters shared by Myc and Ras, and how are these cellular changes linked with oncogene-induced cellular senescence in diffe...
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DNA replication must be tightly regulated to ensure that the genome is accurately duplicated during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA damage ensue. Activated oncogenes promote replicative stress, inducing a DNA damage response (DDR) early in tumorigenesis. Senescence or apoptosis result, forming a barrier against tumour progression. This may prov...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2020
ISSN: 1678-4685,1415-4757
DOI: 10.1590/1678-4685-gmb-2019-0138